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Appropriate Use of Genetic Information

Persistent Issue:
What actions are justified in the interest of the welfare or security of the community?
Central Question:
When should we use personal genetic information to make decisions?
Topic:
Genetics
Course:
Biology
Strategy:
Presentation
Sub-Strategy:
Group Presentation/Peer Review
Grade Level:
9, 10, 11
Lessons in this unit:
  1. Appropriate Use of Genetic Information

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Indiana State Biology Academic Standards

Standard 1: Cellular Chemistry

  • B.1.3 Explain and give examples of how the function and differentiation of cells is influenced by their external environment (e.g., temperature, acidity and the concentration of certain molecules) and changes in these conditions may affect how a cell functions. Cell differentiation not entirely based on genes.

Standard 2: Cellular Structure

  • B.2.4 Explain that all cells contain ribosomes (the key sites for protein synthesis), where genetic material is decoded in order to form unique proteins. Transcription and translation reinforced throughout unit.

Standard 5: Molecular Basis of Heredity

  • B.5.1 Describe the relationship between chromosomes and DNA along with their basic structure and function. B.5.2 Describe how hereditary information passed from parents to offspring is encoded in the regions of DNA molecules called genes.
  • B.5.3 Describe the process by which DNA directs the production of protein within a cell.
  • B.5.4 Explain how the unique shape and activity of each protein is determined by the sequence of its amino acids.
  • B.5.5 Understand that proteins are responsible for the observable traits of an organism and for most of the functions within an organism.
  • B.5.6 Recognize that traits can be structural, physiological or behavioral and can include readily observable characteristics at the organismal level or less recognizable features at the molecular and cellular level.

Standard 7: Genetics

  • B.7.1 Distinguish between dominant and recessive alleles and determine the phenotype that would result from the different possible combinations of alleles in an offspring.
  • B.7.2 Describe dominant, recessive, codominant, sex-linked, incompletely dominant, multiply allelic and polygenic traits and illustrate their inheritance patterns over multiple generations.
  • B.7.3 Determine the likelihood of the appearance of a specific trait in an offspring given the genetic make-up of the parents.
  • B.7.4 Explain the process by which a cell copies its DNA and identify factors that can damage DNA and cause changes in its nucleotide sequence.
  • B.7.5 Explain and demonstrate how inserting, substituting or deleting segments of a DNA molecule can alter a gene, how that gene is then passed to every cell that develops from it and how the results may be beneficial, harmful or have little or no effect on the organism.

Indiana State Science Literacy Standards

  • 9-10.RS.1 Cite specific textual evidence to support analysis of science texts, attending to the precise details of explanations or descriptions.
  • 9-10.RS.6 Analyze the author’s purpose in providing an explanation, describing a procedure, or discussing an experiment in a text, defining the question the author seeks to address.
  • 9-10.RS.10 By the end of grade 10, read and comprehend science texts in the grades 9-10 text complexity band independently and proficiently.
  • 9-10.WS.1 Write arguments focused on discipline-specific content. a. Introduce precise claim(s), distinguish the claim(s) from alternate or opposing claims, and create an organization that establishes clear relationships among the claim(s), counterclaims, reasons, and evidence.
  • 9-10.WS.6 Use technology, including the Internet, to produce, publish, and update individual or shared writing products, taking advantage of technology’s capacity to link to other information and to display information flexibly and dynamically.
  • 9-10.WS.7 Conduct short as well as more sustained research projects to answer a question (including a self-generated question) or solve a problem; narrow or broaden the inquiry when appropriate; synthesize multiple sources on the subject, demonstrating understanding of the subject under investigation.
  • 9-10.WS.8 Gather relevant information from multiple authoritative print and digital sources, using advanced searches effectively; assess the usefulness of each source in answering the research question; integrate information into the text selectivity to maintain the flow of ideas, avoiding plagiarism and following a standard format for citation.
  • 9-10.WS.9 Draw evidence from informational texts to support analysis, reflection, and research.

Next Generation Science Standards(NGSS) Disciplinary Core Ideas

  • HS-LS3-1. Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.
  • HS-LS3-3. Apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population. Tobacco seed germination.
  • HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells.
  • HS-LS1-4. Use a model to illustrate the role of cellular division (mitosis) and differentiation in producing and maintaining complex organisms. Focus on differentiation.

Next Generation Science Standards(NGSS) Science Practices

  • Asking questions (for science)-planning questions for presentation
  • Developing and using models-working with paper models of DNA to protein
  • Planning and carrying out investigations-genes and environment experiment
  • Analyzing and interpreting data-culminating activity, genes and environment experiment
  • Using mathematics and computational thinking-Genes and environment experiment
  • Constructing explanations (for science)-Genes and environment experiment
  • Engaging in argument from evidence-culminating activity
  • Obtaining, evaluating, and communicating information-personal letter

Next Generation Science Standards(NGSS) Crosscutting Concepts

  • Patterns. Students discover patterns in gene expression through experimentation.
  • Cause and effect: Mechanism and explanation. The unit explores the connection between genes and traits, which may or not be cause and effect.
  • Systems and system models. Genes interacting with the environment.
  • Structure and function. Gene structure and function.
  • Stability and change. Society change in light of new gene sequencing technologies.
Lesson Video
Teacher Reflection

1.
Hooking

Mr. Gensic begins the unit/grabs his students’ attention by having them watch a video clip about Miss District of Columbia (Miss America contestant) who had a predisposition for a type of cancer. Mr. Gensic first provides a brief background on her story then asks the students to read a web-based article that he had prepared for them with scaffolding annotations embedded within the article. Mr. Gensic then attempts to relate the story to the students’ lives by asking them if they know anyone who has or died from breast cancer. Finally, he concludes the entry event by asking his students some intriguing/stimulating questions to think about regarding the general use of personal genetic information.
Lesson Video
Teacher Reflection

2.
Tobacco Seed Experiment

Mr. Gensic conducts a lab experiment with his students using tobacco seeds to demonstrate how a gene works when it is activated or inactivated at the cellular level. Mr. Gensic starts the lab activity by demonstrating to his students the steps they need to follow and then asks them to work in groups to conduct the experiment and report their hypothesis of the results.
Lesson Video
Teacher Reflection

3.
Tobacco Seed Experiment (Whiteborad)

Mr. Gensic asks his students to look at the seeds that they setup to germinate last week and report their findings on a whiteboard.
Lesson Video
Teacher Reflection

4.
Tackling Pre-disposition & Gene Activation

Mr. Gensic shares his genetic information with students and attempts to connect it with such concepts as predisposition, gene activation, genotype and phenotype and the general use of personal genetic information.
Lesson Video
Teacher Reflection

5.
Preparation for the Culminating Activity

Mr. Gensic introduces to students the culminating presentation activity that they will complete at the end of the unit. Mr. Gensic divides students into two main groups: one is for more open use of genetic information and the other is for less open use of genetic information. Each group has four specific roles in society and students are encouraged to become advocates of when the use of personal genetic information is justified based on the roles they are assuming: Theme Park Owners, Insurance Executives, Factory Owners, People with Great Genes, Domestic Engineers, Math Teachers, Factory Workers, and Doctors. Mr. Gensic then refers students to the resources available for each group and explains how they can assist them to develop their presentations. He also shares with them his expectations on the outcomes of the culminating activity.
Lesson Video
Teacher Reflection

6.
Student Group Guidelines

Mr. Gensic prepares the students for their presentations. He shares with them an exemplary presentation slide, and distributes question sheets to the question askers within each group.
Lesson Video
Teacher Reflection

7.
Teacher Facilitating Group Work

Mr. Gensic interacts with student-groups. He provides scaffolding in creating the group’s argumentation and helps them make connection between the content knowledge and these arguments.
Lesson Video
Teacher Reflection

8.
Question-Asker Meeting

Mr. Gensic arranges a meeting with the question askers from each group and scaffolds them on their questioning strategies.
Lesson Video
Teacher Reflection

9.
Group Presentation Guidelines

Mr. Gensic sets the stage for the student presentations by sharing the presentations’ order and reminding students of the grading rubric.
Lesson Video
Teacher Reflection

10.
'People with Great Genes' Group Presentation

One student-group presents their position as People with Great Genes to the rest of the class.
Lesson Video
Teacher Reflection

11.
'People with Great Genes' Q&A Session

The students presenting People with Great Genes respond to questions from other groups.
Lesson Video
Teacher Reflection

12.
'Doctors' Group Presentation

Another student-group presents their position as Doctors (against more use of genetics information) to the rest of the class.
Lesson Video
Teacher Reflection

13.
'Doctors' Q&A Session

The students presenting Doctors (against more use of genetics information) respond to questions from other groups.
Seq. Title Size Filetype Download
1 Group Presentation Rubrik and Notetaking 9 Bytes TXT Download File
2 Group Presentation 9 Bytes TXT Download File
3 Group Presentation 13.79 MB MOV Download File